Combined Inhibition of Histamine H1 Receptors and Leukotrienes Reduces Compound 48/80-Induced Contraction of the Human Bronchus in vitro.

摘要: Background/Aims: Bronchial asthma continues to be a big challenge therapy. Mast cells play an important role in allergic asthma. Histamine and leukotrienes are established mast cell mediators, but antihistamines currently no Methods: Human bronchial strips were exposed the activator compound 48/80 (200 μg/ml) isolated organ experiments. Results: The contractile response was not inhibited by H1 receptor antagonist antihistamine chloropyramine (0.3 μmol/l), leukotriene cys-LT1 MK 571 (3 5-lipoxygenase inhibitor 886 (5 cyclo-oxygenase indomethacin tetrodotoxin, or atropine. Chloropyramine, combined with either significantly reduced response. Conclusion: A supra-additive effect is proposed for anti-leukotrienes, which might have relevance human therapy as well; such combination deserves large-scale clinical study. These data also indicate that substances like should denoted activators rather than ‘histamine liberators'.