Looking Beyond Structure: Membrane Phospholipids of Skeletal Muscle Mitochondria

作者: Timothy D. Heden , P. Darrell Neufer , Katsuhiko Funai

DOI: 10.1016/J.TEM.2016.05.007

关键词:

摘要: Skeletal muscle mitochondria are highly dynamic and capable of tremendous expansion to meet cellular energetic demands. Such proliferation in mitochondrial mass requires a synchronized supply enzymes structural phospholipids. While transcriptional regulation has been extensively studied, there is limited information on how membrane lipids generated skeletal muscle. Herein we describe each class phospholipids that constitute membranes synthesized and/or imported, summarize genetic evidence indicating phospholipid composition represents significant modulator respiratory function. We also discuss may mediate the effect diet exercise oxidative metabolism.

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