Effect of antioxidants on sperm genetic damage.

摘要: According to worldwide statistics, between one in four and five couples have fertility problems. These problems are equally distributed males females. Modern lifestyle has obviously increased these problems: endocrine-disrupting chemicals, such as plastic polymer catalysts, alkylphenols, phthalates so on, cosmetic additives seem be strongly involved this problem. Many of compounds increase oxidative stress (OS) thus impair spermatogenesis. The oocyte only a finite capacity, decreasing with maternal age, repair sperm-borne decays. To decrease DNA burden, reducing the sperm damages linked OS is tempting. Antioxidant vitamins often given haphazardly; they not very efficient potentially detrimental. A detailed analysis nucleus mandatory (DNA fragmentation or lack nuclear condensation) prior any treatment. Here we discuss new concepts corresponding therapeutic approaches.