Angiostatic peptides use plasma fibronectin to home to angiogenic vasculature.

摘要: A group of angiogenesis inhibitors are derived from fragments extracellular matrix or blood proteins. Endostatin, antithrombin, and anastellin members this substances. The plasma adhesion proteins fibronectin vitronectin serve as cofactors for these three antiangiogenic Anginex is a synthetic 33-amino acid peptide that was originally modeled to reproduce the β-sheet structure Here, we show anginex initiates polymerization inactive in mice lack fibronectin. shares characteristics with anastellin. Fluorescein-labeled specifically localized angiogenic vessels vivo. This localization dependent on inhibited by an Arg-Gly-Asp peptide. Thus, several physiological dependence role protein interaction apparently form integrin-binding complexes deliver sites angiogenesis. functional convergence factors has important implications therapies.