Intrinsic effects of gold nanoparticles on proliferation and invasion activity in SGC-7901 cells.
作者： YUCHENG WU , QINGQING ZHANG , ZHONGBAO RUAN , YIGANG YIN
DOI: 10.3892/OR.2015.4474
关键词:
摘要: Although biomedical applications of functionalized nanoparticles have taken significant strides, biological characterization unmodified remains unclear. In the present study, we investigated cell viability and invasion activity gastric cancer cells after treatment with gold nanoparticles. The growth SGC-7901 was inhibited significantly 5-nm nanoparticles, decreased markedly. These effects were not seen by different size (10, 20 40 nm). attenuated may be associated expression matrix metalloproteinase 9 intercellular adhesion molecule-1. data indicated that response to strongly their unique size-dependent physiochemical properties. Therefore, provided new evidence for effect on proliferation in vitro, making a contribution application novel therapies cancer.
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