Impact of antibiotic treatment during platinum chemotherapy on survival and recurrence in women with advanced epithelial ovarian cancer.
作者： Laura M. Chambers , Michelle Kuznicki , Meng Yao , Anna Chichura , Morgan Gruner
DOI: 10.1016/J.YGYNO.2020.09.010
关键词:
摘要: Abstract Objective(s) To determine whether antibiotic treatment (ABX) during platinum chemotherapy (PC) for epithelial ovarian cancer (EOC) impacts progression-free survival (PFS) and overall (OS). Study design Retrospective single institution cohort study in women with newly diagnosed stage III/IV EOC (n = 424) who underwent cytoreductive surgery (CRS) PC from 2009 to 2015. ABX >48 h, including against gram-positive (anti-G + ABX) bacteria were recorded. The impact of on PFS OS was assessed using univariate multivariable Cox regression models. Results Of 424 eligible women, 34.7% (n = 147) received ABX, 11.3% (n = 48) treated anti-G + ABX. decreased (17.4 vs. 23.1 months, HR 1.50, 95% CI 1.20–1.88, p Conclusion(s) In this retrospective advanced undergoing PC, associated OS. Mechanistic studies are needed investigate the negative upon response EOC.
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