Impact of family history of metabolic traits on severity of non-alcoholic steatohepatitis related cirrhosis: A cross-sectional study.
作者： Ajeet S Bhadoria , Chandan K Kedarisetty , Chhagan Bihari , Guresh Kumar , Ankur Jindal
DOI: 10.1111/LIV.13396
关键词:
摘要: Background and aims Familial aggregation of metabolic traits with fatty liver disease is well documented. However, there scarcity data regarding such association non-alcoholic steato-hepatitis (NASH) related cirrhosis. This study was aimed to explore the family history severity cirrhosis. Methods In a cross-sectional study, all consecutive patients NASH cirrhosis presenting our tertiary care centre were included. Family history, personal demographic characteristics, medical anthropometric measurements laboratory recorded. Results Of 1,133 cirrhotics (68.1% males, age 51.4±10.9 years); 779 (68.8%) had for traits. These lower at diagnosis (45.4±10.6 vs. 49.6±11.2yr), higher CTP score (7.8±1.9 6.6±1.5), MELD (12.9±6.1 10.9±4.1) more incidence decompensation in form ascites (46.3% 25.7%), jaundice (12.1%vs.6.2%) hepatic encephalopathy (26.1% 11.0%). Patients traits, an increased risk early 15 (OR:6.6, 95%CI 3.8-11.5) ≥1 features (OR:4.2, 2.9-6.1). diabetes alone, also MELD>15 (OR: 4.3, 2.4-5.3, P<0.001). Conclusion Family are associated so, has prognostic importance cirrhotics. This article protected by copyright. All rights reserved.
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