Advanced glycation end products are elevated in cystic fibrosis-related diabetes and correlate with worse lung function
作者： William R. Hunt , Beth R. Helfman , Nael A. McCarty , Jason M. Hansen
DOI: 10.1016/J.JCF.2015.12.011
关键词:
摘要: Abstract Background The onset of cystic fibrosis-related diabetes (CFRD) exacerbates lung function decline and increases mortality. One pathway that may worsen the dysfunction associated with CFRD is receptor for advanced glycation end products (RAGE) its ligands. Methods Human plasma was obtained from age-matched healthy, CF patients. Plasma RAGE ligands (i.e. products, S100A12, high-mobility group protein B1) soluble (sRAGE) levels were measured. Results patients had elevated AGEs S100A12. Soluble RAGE, a ligand decoy receptor, not significantly different between groups. AGE S100A12 negative correlations FEV 1 . Conclusions are in correlate negatively did have significant sRAGE, suggesting there be heightened binding activation exacerbating proinflammatory pathways.
cysticfibrosisjournal.com参考文章(45)
Maria Entezari, Daniel J Weiss, Ravikumar Sitapara, Laurie Whittaker, Matthew J Wargo, JianHua Li, Haichao Wang, Huan Yang, Lokesh Sharma, Binh D Phan, Mohammad Javdan, Sangeeta S Chavan, Edmund J Miller, Kevin J Tracey, Lin L Mantell, Inhibition of high-mobility group box 1 protein (HMGB1) enhances bacterial clearance and protects against Pseudomonas Aeruginosa pneumonia in cystic fibrosis. Molecular Medicine. ,vol. 18, pp. 477- 485 ,(2012) , 10.2119/MOLMED.2012.00024
Roman Nowygrod, Antonio Migheli, David Pinsky, Yu Shan Zou, Shi Du Yan, Ann Marie Schmidt, David Stern, Jerold Brett, Alan Shaw, Craig Przysiecki, Elliott Weidman, Michael Neeper, Survey of the Distribution of a Newly Characterized Receptor for Advanced Glycation End Products in Tissues American Journal of Pathology. ,vol. 143, pp. 1699- 1712 ,(1993)
M Neeper, A.M. Schmidt, J Brett, S.D. Yan, F Wang, Y.C. Pan, K Elliston, D Stern, A Shaw, Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. Journal of Biological Chemistry. ,vol. 267, pp. 14998- 15004 ,(1992) , 10.1016/S0021-9258(18)42138-2
A.M. Schmidt, M Vianna, M Gerlach, J Brett, J Ryan, J Kao, C Esposito, H Hegarty, W Hurley, M Clauss, Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. Journal of Biological Chemistry. ,vol. 267, pp. 14987- 14997 ,(1992) , 10.1016/S0021-9258(18)42137-0
Katsuya Ishihara, Kae Tsutsumi, Shiho Kawane, Motowo Nakajima, Tatsuhiko Kasaoka, The receptor for advanced glycation end-products (RAGE) directly binds to ERK by a D-domain-like docking site FEBS Letters. ,vol. 550, pp. 107- 113 ,(2003) , 10.1016/S0014-5793(03)00846-9
Steven M. Rowe, Patricia L. Jackson, Gang Liu, Mathew Hardison, Alessandra Livraghi, G. Martin Solomon, D. Brent McQuaid, Brett D. Noerager, Amit Gaggar, J. P. Clancy, Wanda O'Neal, Eric J. Sorscher, Edward Abraham, J. Edwin Blalock, Potential Role of High-Mobility Group Box 1 in Cystic Fibrosis Airway Disease American Journal of Respiratory and Critical Care Medicine. ,vol. 178, pp. 822- 831 ,(2008) , 10.1164/RCCM.200712-1894OC
Nina Demling, Carsten Ehrhardt, Michael Kasper, Michael Laue, Lilla Knels, Ernst Peter Rieber, Promotion of cell adherence and spreading: a novel function of RAGE, the highly selective differentiation marker of human alveolar epithelial type I cells Cell and Tissue Research. ,vol. 323, pp. 475- 488 ,(2006) , 10.1007/S00441-005-0069-0
Mouza T. Goova, Jun Li, Thomas Kislinger, Wu Qu, Yan Lu, Loredana G. Bucciarelli, Sarah Nowygrod, Bonnie M. Wolf, Xzabia Caliste, Shi Fang Yan, David M. Stern, Ann Marie Schmidt, Blockade of Receptor for Advanced Glycation End-Products Restores Effective Wound Healing in Diabetic Mice American Journal of Pathology. ,vol. 159, pp. 513- 525 ,(2001) , 10.1016/S0002-9440(10)61723-3
Pari Malherbe, J.Grayson Richards, Hélène Gaillard, Annick Thompson, Catherine Diener, Angelika Schuler, Gerda Huber, cDNA cloning of a novel secreted isoform of the human receptor for advanced glycation end products and characterization of cells co-expressing cell-surface scavenger receptors and Swedish mutant amyloid precursor protein. Molecular Brain Research. ,vol. 71, pp. 159- 170 ,(1999) , 10.1016/S0169-328X(99)00174-6
Eirini Christaki, Steven M. Opal, James C. Keith, Nubar Kessimian, John E. Palardy, Nicolas A. Parejo, Xiang Yang Tan, Nicole Piche-Nicholas, Lioudmila Tchistiakova, George P. Vlasuk, Kathleen M. Shields, Jeffrey L. Feldman, Edward R. LaVallie, Maya Arai, William Mounts, Debra D. Pittman, A monoclonal antibody against RAGE alters gene expression and is protective in experimental models of sepsis and pneumococcal pneumonia. Shock. ,vol. 35, pp. 492- 498 ,(2011) , 10.1097/SHK.0B013E31820B2E1C