Design of hierarchical electrocatalytic mediator for one step, selective screening of biomolecules in biological fluid samples

摘要: Active electrocatalytic electrode designs are needed for the sensitive and selective detection of a single or multi-active biomolecule among biological components. We report design hierarchical NiO catalyst (HNC) one-step monitoring bioactive molecules such as ascorbic acid (AA), dopamine (DA), uric (UA). The novel mesostructured geometries, active surface sites, multi-diffused spaces easy electron movement through gaps provide highly designing surface. Controlled HNC architecture along electrode-design domains having double-head branches spread out both sides dipole-like rod may lead to vital transfer fast response signaling multi-bioactive in one-shot triggering individually simultaneously. Electrochemical analyses showed evidence that proposed can detect each component up 0.02 µM. Sensitive 1.127, 0.02, 0.978 µM wide-range responses 25–800, 2–60, 10–000 µM AA, DA, UA, respectively, were observed. simultaneous UA real urine samples one step under different potentials realized. Thus, HNC-modified monitor evaluate coexistence biomolecules simultaneously multi-components. electrochemical oxidation at corresponding DPV peaks with losing 2e−/2H+.