Estimating severity of illness and disability in Frontotemporal Dementia: Preliminary analysis of the Dementia Disability Rating (DDR)

摘要: BACKGROUND Current measures of severity and disability do not stage or track the progression in frontotemporal dementia (FTD) well. We investigated reliability newly developed Dementia Disability Rating (DDR) measurement staging illness FTD Alzheimer type (DAT). MATERIAL/ METHODS studied 48 consecutive patients Johns Hopkins Young-Onset Dementias Clinic, with diagnoses DAT, FTD, vascular "other" cognitive disorder (CDNOS). Cases were scored on CDR DDR by three trained raters, based neuropsychiatric examinations performed at first visit other assessments within preceding year. Consensus ratings assigned conference. RESULTS Inter-rater correlations sum ranks scores for DAT ranged from 0.88 to 0.91, 0.89-0.96 CDNOS 0.85-0.97. Similar observed rank FTD. Correlations summary 0.67-0.91 0.79-0.91, as compared data: 0.87-0.92 (p<0.0001) 0.80-0.93 respectively. In correlation between was higher than patients, whereas high both groups. CONCLUSIONS These preliminary data indicate comparable CDR. Convergent validity demonstrated DDR.