Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat.

摘要: Seventeen adult cats were chronically implanted with electrodes for polygraphic recordings in order to assess the role of catecholamines arousal effects oral administrations modafinil, a presumed noradrenergic agonist, and amphetamine, well-known catecholamine-releasing agent. Whereas both modafinil (1, 2.5 5 mg/kg) amphetamine (0.25, 0.5 1 caused significant dose-dependent increase wakefulness brain temperature, but not elicited marked signs behavioral excitation. Pretreatments alpha-methyl-DL-p-tyrosine methyl ester (50 mg/kg, i.p.), an inhibitor catecholamine synthesis, almost completely prevented (0.25 mg/kg), only slightly reduced duration waking effect (2.5 mg/kg). phentolamine (10 prazosin (1.5 per os) propranolol (5 alpha-, alpha 1- beta-receptor antagonist, respectively, attenuated significantly (1 same as below) below). Intraperitoneal injections haloperidol (0.5 dopamine-receptor blocked modafinil. The enhanced by pretreatment yohimbine 2-receptor antagonist. These results suggest that does depend on availability endogenous from enhancement activity may be mainly due dopamine release.