Hemoglobin F and hemoglobin E/beta-thalassemia.
作者： D. C. Rees
DOI: 10.1097/00043426-200011000-00025
关键词:
摘要: Hemoglobin (Hb) F levels are high and variable in Hb E/beta-thalassemia, ranging from 10% to 80%. The secondary expansion of the erythron with ineffective erythropoiesis selection favor cells able make more gamma-globin. variability reflects complex processes involved production. Important determinants include age, alpha-thalassemia, genetic gamma-chain synthesis. Overall, percentage correlates total hemoglobin decreases steadily age. alpha-thalassemia is associated a lower but higher level E/beta-thalassemia.
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