Synthesis, structure, NO donor activity of iron–sulfur nitrosyl complex with 2-aminophenol-2-yl and its antiproliferative activity against human cancer cells
作者： NA Sanina , GI Kozub , OS Zhukova , NS Emel’yanova , TA Kondrat’eva
DOI: 10.1080/00958972.2013.848980
关键词:
摘要: A new tetranitrosyl binuclear iron complex, [Fe2(SC6H6N)2(NO)4] (1), has been synthesized by two methods. Molecular and crystalline structure of 1 were determined X-ray analysis; the complex is “μ-S” type with ~2.7052(4) between irons. The compound crystallizes in monoclinic, space group P21/n, Z = 2; parameters unit cell: a = 6.6257(2) A, b = 7.9337(2) c = 16.7858(4) β = 96.742(2)°, V = 876.26(4) A3. Parameters Mossbauer spectrum for are: isomer shift δFe = 0.096(1) mm/s, quadrupole splitting ΔEQ = 1.122(1) line width 0.264(1) mm/s at 293 K. As follows from electrochemical analysis aqueous solutions 1, it generates NO protonic media without additional activation. amount rate its activation are much higher acidic than neutral alkali ones. constants hydrolytic decomposition calculated. geometry electronic isolated studied using density functional theory. Differential...
sci-hub.se 参考文章(41)
NA Sanina, OA Rakova, SM Aldoshin, II Chuev, EG Atovmyan, NS Ovanesyan, None, Synthesis and X-ray and Spectral Study of the Compounds [Q4N]2[Fe2(S2O3)2(NO)4] (Q = Me, Et, n-Pr, n-Bu) Russian Journal of Coordination Chemistry. ,vol. 27, pp. 179- 183 ,(2001) , 10.1023/A:1009598228585
Arnold Weissberger, Erich S. Proskauer, Emory E. Toops, Organic Solvents: Physical Properties and Methods of Purification ,(1970)
Sreenivas Kanugula, Meng Xu-Welliver, Anthony E. Pegg, Liping Liu, Inactivation and Degradation of O6-Alkylguanine-DNA Alkyltransferase after Reaction with Nitric Oxide Cancer Research. ,vol. 62, pp. 3037- 3043 ,(2002)
James C. Dabrowiak, Metals in Medicine ,(2009)
Frank Traganos, Simona Borgo, Izhar Hasan, Basil Rigas, Eddy Castillo, Jennie L. Williams, Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) alter the kinetics of human colon cancer cell lines more effectively than traditional NSAIDs: implications for colon cancer chemoprevention. Cancer Research. ,vol. 61, pp. 3285- 3289 ,(2001)
Simone Mocellin, Nitric oxide: cancer target or anticancer agent? Current Cancer Drug Targets. ,vol. 9, pp. 214- 236 ,(2009) , 10.2174/156800909787581015
Anthony R. Butler, Ian L. Megson, Non-Heme Iron Nitrosyls in Biology Chemical Reviews. ,vol. 102, pp. 1155- 1166 ,(2002) , 10.1021/CR000076D
NA Sanina, LA Syrtsova, NI Shkondina, ES Malkova, AI Kotel’nikov, SM Aldoshin, None, Hemoglobin-stabilized tetranitrosyl binuclear iron complex with pyridine-2-yl in aqueous solutions Russian Chemical Bulletin. ,vol. 56, pp. 761- 766 ,(2007) , 10.1007/S11172-007-0114-0
Yaw-Dong Lang, Shwu-Fen Chang, Leng-Fang Wang, Chung-Ming Chen, Chymase mediates paraquat-induced collagen production in human lung fibroblasts. Toxicology Letters. ,vol. 193, pp. 19- 25 ,(2010) , 10.1016/J.TOXLET.2009.12.001
NS Emelyanova, AF Shestakov, IV Sulimenkov, TN Rudneva, NA Sanina, SM Aldoshin, None, The structures of the dicationic tetranitrosyl iron complex with cysteamine [Fe2S2(CH2CH2NH3)2(NO)4]2+ and its decomposition products in protic media: an experimental and theoretical study Russian Chemical Bulletin. ,vol. 61, pp. 1- 11 ,(2012) , 10.1007/S11172-012-0001-1