Bioconjugated Rhenium(I) Complexes with Amino Acid Derivatives: Synthesis, Photophysical Properties, and Cell Imaging Studies

摘要: The synthesis of a series bioconjugated fac tricarbonyl rhenium bis-imine complexes with amino acid ester derivatives and their application in fluorescent microscopy cell imaging is reported. A range meta- para-bioconjugated pyridyl were synthesized, photophysical properties analyzed upon coordination to fac-[Re(bipy)(CO)3(CF3SO3)]. Their long lifetimes (270–370 ns) large Stokes shifts (>140 nm) suggested the new could be strong candidates for applications. All species taken up by MCF-7 cells seemed have distinct localization pattern. However, while incubated para had an anomalous cellular growth pattern suffered from photobleaching irradiation, promoting death, those meta behaved normal manner did not photobleach, emphasizing importance ligand design when it necessary optimum outcome: i.e., imagin...