The glyoxylate cycle is required for fungal virulence

摘要: Candida albicans, a normal component of the mammalian gastrointestinal flora, is responsible for most fungal infections in immunosuppressed patients. normally phagocytosed by macrophages and neutrophils, which secrete cytokines induce hyphal development this fungus1,2. Neutropenic patients, deficient these immune cells, are particularly susceptible to systemic candidiasis3,4. Here we use genome-wide expression profiles related yeast Saccharomyces cerevisiae obtain signature events that take place fungus on ingestion macrophage. Live S. cells isolated from phagolysosome induced genes glyoxylate cycle, metabolic pathway permits two-carbon compounds as carbon sources. In C. phagocytosis also upregulates principal enzymes isocitrate lyase (ICL1) malate synthase (MLS1). albicans mutants lacking ICL1 markedly less virulent mice than wild type. These findings fungi, conjunction with reports both upregulated required virulence Mycobacterium tuberculosis5,6, demonstrate wide-ranging significance cycle microbial pathogenesis.