Chromosome aberrations in lymphocytes after occupational exposure to lead and cadmium.

作者: M. Bauchinger , E. Schmid , H.J. Einbrodt , J. Dresp

DOI: 10.1016/0165-1218(76)90023-9

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摘要: Abstract Chromosomes were analysed in peripheral lymphocytes of 24 workers a zinc smelting plant who had increased blood levels lead and cadmium. The number cells with structural chromosome aberrations was significantly as compared 15 controls. observed damage mainly the chromatid type (single breaks exchanges) accompanied by acentric fragments. cannot be causally related to cadmium because additionally exposed zinc. However, from existing cytogenetic data on heavy metals an effect could well deduced, although possible synergistic effects several metal compounds, especially under conditions, vivo, excluded.

参考文章(9)
Yukimasa Shiraishi, Cytogenetic studies in 12 patients with Itai-Itai disease Human Genetics. ,vol. 27, pp. 31- 44 ,(1975) , 10.1007/BF00283501
Yukimasa SHIRAISHI, Hiromu KURAHASHI, Tosihide H. YOSIDA, Chromosomal Aberrations in cultured Human Leucocytes induced by Cadmium Sulfide Proceedings of the Japan Academy. ,vol. 48, pp. 133- 137 ,(1972) , 10.2183/PJAB1945.48.133
M. L. O'RIORDAN, H. J. EVANS, Absence of Significant Chromosome Damage in Males Occupationally Exposed to Lead Nature. ,vol. 247, pp. 50- 53 ,(1974) , 10.1038/247050A0
M. Bauchinger, G. Röhr, Chromosome analyses in cell cultures of Chinese hamster after application of CdSO4 Mutation Research\/environmental Mutagenesis and Related Subjects. ,vol. 38, pp. 102- 103 ,(1976) , 10.1016/0165-1161(76)90007-8
Gillian R. Paton, A.C. Allison, Chromosome damage in human cell cultures induced by metal salts Mutation Research. ,vol. 16, pp. 332- 336 ,(1972) , 10.1016/0027-5107(72)90166-2
M Bauchinger, E Schmid, D Schmidt, Chromosomenanalyse bei Verkehrspolizisten mit Erhöhter Bleilast Mutation Research. ,vol. 16, pp. 407- 412 ,(1972) , 10.1016/0027-5107(72)90209-6
E Schmid, M Bauchinger, S Pietruck, G Hall, Die cytogenetische wirkung von blei in menschlichen peripheren lymphocyten in vitro und in vivo Mutation Research. ,vol. 16, pp. 401- 406 ,(1972) , 10.1016/0027-5107(72)90208-4
H. J. Einbrodt, J. Rosmanith, U. Primas, F. Thomas, Der Blutblei-Spiegel bei Kindern in einem kontaminierten Industriegebiet Naturwissenschaften. ,vol. 61, pp. 39- 40 ,(1974) , 10.1007/BF00602903