Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians.
作者： Fu-Hui Xiao , Xiao-Qiong Chen , Qin Yu , Yunshuang Ye , Yao-Wen Liu
关键词:
摘要: Centenarians (CENs) are excellent subjects to study the mechanisms of human longevity and healthy aging. Here, we analyzed transcriptomes 76 centenarians, 54 centenarian-children, 41 spouses centenarian-children by RNA sequencing found that, among significantly differentially expressed genes (SDEGs) exhibited CENs, autophagy-lysosomal pathway is up-regulated. Overexpression several from this pathway, CTSB, ATP6V0C, ATG4D, WIPI1, could promote autophagy delay senescence in cultured IMR-90 cells, while overexpression Drosophila homolog Atg18a, extended life span transgenic flies. Interestingly, enhanced activity be partially passed on their offspring, as manifested higher levels both autophagy-encoding serum beclin 1 (BECN1). In light normal age-related decline functions, these findings provide a compelling explanation for achieving in, at least, female given gender bias our collected samples, suggest that waste-cleaning via may serve conserved mechanism prolong humans.
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