The inhibitor of apoptosis protein survivin is associated with high-risk behavior of neuroblastoma

摘要: Abstract Background/Purpose: Apoptotic factors inducing or preventing cell death may intrinsically govern the behavior of some tumors. Survivin is a recently described member inhibitor apoptosis protein (IAP) family, that expressed in cycle–dependent manner and found tumors unfavorable histology. This study examines presence several apoptotic factors, including survivin, neuroblastoma (NB) Clues to survivin's function NB are provided by examining its association with dynamics lines. Methods: Expression panel were quantified 15 related before chemotherapy 3 lines (NB7, NB10, NB16). other as well N- myc amplification primary was correlated recurrent disease outcome. Proliferation rate, assays, cycle analysis, drug- immune-mediated assessed evaluated context differential survivin gene expression. Results: All 7 went on recur whereas expression absent all 8 into remission. amplified 4 (57.1%) Of cured, Fas (38%), TRAIL-R1 6 (75%) tumor necrosis factor (TNF)-R1 (100%), these pro-apoptotic receptors present only 1 (14%), (57%) recur, respectively. lines, NB10 least displayed lowest proliferation index, had fewest number cells G2/M (mitotic) phase cycle. Furthermore, also most sensitive TNF-related apoptosis-inducing ligand (TRAIL) etoposide-induced death. Conclusions: In tumors, associated high risk prognosis, receptor more abundant favorable prognosis. this small series, appeared be predictive than amplification. dependent, greater rates resistance become useful prognostic marker could potential target for treatment tumor. J Pediatr Surg 36:1785-1791. Copyright © 2001 W.B. Saunders Company.