Nonalcoholic fatty liver disease and the renin-angiotensin system: Implications for treatment.
作者： Paschalis Paschos , Konstantinos Tziomalos
关键词:
摘要: Nonalcoholic fatty liver disease (NAFLD) is the commonest in Western countries. Treatment of NAFLD currently based on lifestyle measures and no effective pharmacologic treatment available so far. Emerging evidence, mainly from animal studies, suggests that renin-angiotensin-aldosterone system may be major importance pathogenesis indicates angiotensin-converting enzyme inhibitors (ACE-I) angiotensin receptor blockers (ARBs) as a potentially useful therapeutic approach. However, data human studies are limited contradictory. In addition, there few randomized controlled trials (RCTs) effects ACE-I or ARB patients with most retrospective pilot prospective post hoc analyses clinical trials. Accordingly, more larger RCTs needed to directly assess effectiveness ARBs NAFLD.
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