Hepatoprotective Effects of MHY3200 on High-Fat, Diet-Induced, Non-Alcoholic Fatty Liver Disease in Rats

摘要: This study investigated the effects of 2-(4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy)-2,2-difluoroacetic acid (MHY3200) on high-fat diet (HFD)-induced hepatic lipid accumulation and inflammation. The measurement peroxisome proliferator-activated receptor (PPAR)α activity by using a luciferase assay indicated that MHY3200 was more potent than known PPARα agonist, WY14643, in AC2F cells. Six-month-old male SD rats were fed chow or HFD for 1 month, after, with without added (1 2 mg/kg/day) 4 weeks. oral administration caused significant decrease serum triglyceride (TG), glucose, alanine aminotransferase, insulin, as well slight level free fatty aspartate transaminase. No weight gain detected when compared rats, TG content also attenuated MHY3200. Furthermore, phosphorylation ER stress marker, inositol-requiring kinase its downstream gene, c-Jun N-terminal kinase, addition to serine insulin substrate suppressed Consistent these results, reduced levels activation protein-1, cyclooxygenase-2, inducible nitric oxide synthase. Our results suggested ameliorated HFD-induced inflammation, improved resistance through activation.