Effects of cadmium and zinc on canine tracheal bioelectric properties

摘要: Abstract Luminal exposure of excised tracheal epithelium to Cd(NO3)2 (3 × 10−3 m ) inhibited short circuit current by 50% and increased dc conductance 500%. Zn(NO3)2 reduced 24% but did not affect current. Exposure both salts each) induced a slightly greater inhibition than alone had no significant effect on conductance. Submucosal at least 10- 20-fold increase in The potency, compared luminal exposure, was 10-fold greater. about as potent Cd(NO3)2. little Inhibition submucosal additive submucosal, Zn protected against the Cd. Our results support interpretation that there are two classes Cd binding ligands accessible from bathing solution. competes with for associated metal-induced changes tissue does trigger increase. Groups linked interact Zn's affinity or access these groups is negligible. Addition either metal bath leads interaction participate has