Topical Metronidazole Therapy for Rosacea

摘要: • Forty patients with rosacea were treated topically 0.75% metronidazole gel in a randomized split-face double-blind paired-comparison trial. With twice-daily applications, 36.7, 48.5, and 65.1 mean percent reductions total papules pustules noted over baseline at 3, 6, 9 weeks, respectively, on the side of face receiving therapy. Therapy vehicle alone produced maximum reduction 14.9 nine weeks. Erythema also responded but was less improved by end weeks A mild increase telangiectasia both actively placebo-treated sides. The locally well tolerated. Only two 40 failed to complete trial, because flares (one days, one five weeks). No systemic symptoms noted, no consistent abnormalities found results laboratory studies (hematology, chemistry, urinalysis). Topical therapy appears be safe efficacious treatment moderate severe rosacea. ( Arch Dermatol 1987;123:609-614)