摘要: In view of the many discordant findings in previous studies regarding genetics prelingual deafness, family data (133 nuclear families and 25 pedigrees) were gathered from India. Analysis these has revealed that defect is primarily genetic, which agreement with earlier findings. Segregation analysis was performed to compare various autosomal diallelic one-locus multilocus models. Our most parsimonious model for deafness it controlled by recessive genes at a pair unlinked loci. Individuals are affected if only they homozygous both The likelihood present under this two-locus multiple homozygosis least 10(8) times higher than models examined studies. This also best-fitting among other plausible
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