Zn-HA/Bi-HA biphasic coatings on Titanium: Fabrication, characterization, antibacterial and biological activity.
作者： Qing Bi , Xian Song , Yujia Chen , Yaping Zheng , Ping Yin
DOI: 10.1016/J.COLSURFB.2020.110813
关键词:
摘要: Abstract Hydroxyapatite (HA) coatings have been of important as biocompatible for dental and bone tissue engineering application. However, the poor antibacterial performance weak biological activity HA limited their clinical applications. As a strategy to improve HA, Zinc bismuth ions were incorporated into lattice by substituting Ca2+ ions, respectively, thus zinc substituted hydroxyapatite/bismuth hydroxyapatite (Zn-HA/Bi-HA) biphasic on titanium plates with various ratios fabricated via sol-gel dip-coating processes. The purity Zn-HA Bi-HA phase was confirmed X-ray diffraction (XRD) test. showed slower dissolution rate than pure coating. Furthermore, Zn-HA/Bi-HA reveal good biomineralization in simulated body fluid (SBF) forming regular spherical apatite agglomerates. Moreover, exhibited that improved antimicrobial against Escherichia coli (E. coli) Staphylococcus aureus (S. aureus) compared coatings. CCK-8 assays demonstrate no toxicity MG63 cells, Zn-HA/Bi-HA2 (Zn-HA:Bi-HA=64:1) coating is more effective enhance proliferation cells other This finding suggests are promising candidates biomedical
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