Heterologous expression and characterization of a "Pseudomature" form of taxadiene synthase involved in paclitaxel (Taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction.

作者: David C Williams , Mark R Wildung , Alan Qingwu Jin , Dolan Dalal , John S Oliver

DOI: 10.1006/ABBI.2000.1865

关键词:

摘要: … Paclitaxel is the generic name for Taxol, which is now a registered trademark of Bristol-Meyers Squibb. Because … familiarity of the word Taxol, we use it in this paper in lieu of paclitaxel. …

参考文章(54)
Edward M. Davis, Rodney Croteau, Cyclization Enzymes in the Biosynthesis of Monoterpenes, Sesquiterpenes, and Diterpenes Springer Berlin Heidelberg. pp. 53- 95 ,(2000) , 10.1007/3-540-48146-X_2
John W. Porter, Sandra L. Spurgeon, Biosynthesis of Isoprenoid Compounds ,(1981)
Sukh Dev, Renuka Misra, CRC handbook of terpenoids--Diterpenoids CRC Press. ,(1985)
E.E. van Tamelen, K.B. Sharpless, Positional selectivity during controlled oxidation of polyolefins Tetrahedron Letters. ,vol. 8, pp. 2655- 2659 ,(1967) , 10.1016/S0040-4039(01)89969-X
Kurt Wagschal, Thomas J. Savage, Rodney Croteau, Isotopically sensitive branching as a tool for evaluating multiple product formation by monoterpene cyclases Tetrahedron. ,vol. 47, pp. 5933- 5944 ,(1991) , 10.1016/S0040-4020(01)86486-3
Jean I.M. Rajaonarivony, Jonathan Gershenzon, Rodney Croteau, Characterization and Mechanism of 4S-Limonene Synthase, a Monoterpene Cyclase from the Glandular Trichomes of Peppermint (Mentha x piperita) Archives of Biochemistry and Biophysics. ,vol. 296, pp. 49- 57 ,(1992) , 10.1016/0003-9861(92)90543-6
Ylva Gavel, Gunnar von Heijne, A conserved cleavage-site motif in chloroplast transit peptides FEBS Letters. ,vol. 261, pp. 455- 458 ,(1990) , 10.1016/0014-5793(90)80614-O
Rodney. Croteau, Biosynthesis and catabolism of monoterpenoids Chemical Reviews. ,vol. 87, pp. 929- 954 ,(1987) , 10.1021/CR00081A004