Chemistry for peptide and protein PEGylation.

作者: J.M. Harris , M.J. Roberts , M.D. Bentley

DOI: 10.1016/S0169-409X(02)00022-4

关键词:

摘要: … from zero to the number of ε- and α-amine groups in the protein. For a protein molecule that … method, the polyethylene glycol moiety may be attached at a number of different amine sites. …

参考文章(65)
Samuel Zalipsky, Chyi Lee, Use of Functionalized Poly(Ethylene Glycol)s for Modification of Polypeptides Poly(Ethylene Glycol) Chemistry. pp. 347- 370 ,(1992) , 10.1007/978-1-4899-0703-5_21
D. Kafkewitz, C. R. Verhoest, M. L. Nucci, F. F. Davis, A. Abuchowski, T. Van Es, G. M. Kazo, A. T. Viau, Cancer therapy with chemically modified enzymes. I. Antitumor properties of polyethylene glycol-asparaginase conjugates. Cancer biochemistry biophysics. ,vol. 7, pp. 175- 186 ,(1984)
Gert Hooftman, Sabine Herman, Etienne Schacht, Review : Poly(ethylene glycol)s with reactive endgroups. II. Practical consideration for the preparation of protein-PEG conjugates Journal of Bioactive and Compatible Polymers. ,vol. 11, pp. 135- 159 ,(1996) , 10.1177/088391159601100205
A Abuchowski, T van Es, N C Palczuk, F F Davis, Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol. Journal of Biological Chemistry. ,vol. 252, pp. 3578- 3581 ,(1977) , 10.1016/S0021-9258(17)40291-2
J. Milton Harris, M. R. Sedaghat-Herati, Preparation and use of polyethylene glycol propionaldehyde ,(1990)
Smadar Cohen, Toshio Yoshioka, Melissa Lucarelli, Lena H. Hwang, Robert Langer, Controlled Delivery Systems for Proteins Based on Poly(Lactic/Glycolic Acid) Microspheres Pharmaceutical Research. ,vol. 8, pp. 713- 720 ,(1991) , 10.1023/A:1015841715384
A Abuchowski, J R McCoy, N C Palczuk, T van Es, F F Davis, Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase. Journal of Biological Chemistry. ,vol. 252, pp. 3582- 3586 ,(1977) , 10.1016/S0021-9258(17)40292-4