Chromosomal abnormalities in leiomyosarcomas.

摘要: Thirty-eight tumors from 30 patients diagnosed as leiomyosarcoma were cytogenetically assessed after short term culture. The specimens obtained the retroperitoneum, gastrointestinal tract, and extremities. Chromosomal abnormalities present in 18 13 patients; 15 had clonal changes, whereas 3 numerous nonclonal changes. Ten 10 normal karyotypes no results other 7 patients. Of with chromosomal aberrations, 4 near-diploid (3 hypo- one hyperdiploid) modes, 8 polyploid, bimodal. No specific karyotypic change appeared to characterize leiomyosarcomas, although involvement of some chromosomes more frequent than others. A comparison our findings those reported literature revealed certain consistent structural rearrangements involving 1, 7, 10, 13, 14 at bands 1p36, 1p32, 1p13, 1q32, 7p11.1-p21, 7q32, 10q22, 13q14, 14p11, respectively. Other less frequently rearranged 3p13-p22, 3q21, 4q13-q23, 6q15-q21, 7q11.2-q22, 12q13-q14, 17q12-q25, 19q13.3-q13.4, 20q12-q13.1. Numerical changes included recurrent loss 4, 9, 14, 15, 16, 18, 21, 22. Identification these is important that it may predict existence oncogenes, tumor suppressor genes, and/or growth factor genes sites. Subsequent molecular analysis might then lead identification involved ultimately a better understanding pathogenesis leiomyosarcomas.