Can angiotensin-converting enzyme inhibitors reverse atherosclerosis?

摘要: Angiotensin II, a potent vasoconstrictor, is mainly present in the vascular endothelium. Multiple studies have confirmed that angiotensin-converting enzyme (ACE) inhibitors, which block formation of angiotensin lower blood pressure and also improve heart failure. These agents not only beneficial hemodynamic effects but bestow additional benefits on function prevent clinical cardiovascular events patients at risk for coronary artery disease. latter may represent ACE inhibitors local endocrine pathways, inflammatory processes, atherosclerosis taking place within arterial wall. Current evidence suggests that, although substantially reverse atherosclerotic plaque already present, they slow progression such lesions. In addition, by modulating pathways adjacent to lesion, stabilize an unstable therefore decrease rupture its complications.