Control of plasmid replication: theoretical considerations and practical solutions.

摘要: The life cycle of bacterial plasmids involves 2 different processes, replication (rep) and partitioning (par). Both these processes have to be controlled in order secure stable inheritance a plasmid growing population bacteria. crucial genetic information for (control of) (21) (31,41) is present on the themselves. seem independent each other since deletion thepar region does not affect copy-number control although it results unstable (41). Furthermore, 1 can replaced by that another, giving totally same copy number as initial replicon (42). A third system adds stability plasmids, theccd ofcelldivision) inhibits cell division cells containing only (45).