Improved solubility and oral bioavailability of apigenin via Soluplus/Pluronic F127 binary mixed micelles system
作者： Zhenhai Zhang , Changchang Cui , Fang Wei , Huixia Lv
DOI: 10.1080/03639045.2017.1313857
关键词:
摘要: AbstractThe aim of this study was to develop a novel mix micelles system composing two biocompatible copolymers Soluplus® and Pluronic F127 improve the solubility, oral bioavailability insoluble drug apigenin (AP) as model drug. The AP-loaded mixed (AP-M) were prepared by ethanol thin-film hydration method. formed optimal formulation AP-M provided with small size (178.5 nm) spherical shape at ratio 4:1 (Soluplus®:Pluronic F127), well increasing solubility 5.61 mg/mL in water which about 3442-fold compared that free AP. entrapment efficiency loading 95.72 5.32%, respectively, sustained release obtained vitro indicated. Transcellular transport showed cell uptake AP increased Caco-2 models. 4.03-fold SD rats, indicating is an industrially fea...
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