Sulphadimidine acetylation test for classification of patients as slow or rapid inactivators of isoniazid.

摘要: Sulphadimidine acetylation studies were undertaken in 103 patients, 52 of whom had been classified as slow and 51 rapid inactivators isoniazid by a standard microbiological assay method. Each patient received sulphadimidine mouth dose 44 mg./kg. body weight, free total estimated blood urine collected at six hours. The findings suggest that patients may be if the proportion acetylated (total minus free) is (a) less than 25% or (b) 70% urine. test easy to perform result available same day; specimens for can stored room temperature over week without any loss drug.