Codependency of Metabolism and Epigenetics Drives Cancer Progression: A Review.

摘要: Cancer is widely considered to be a set of genetic diseases that are currently classified by tissue and cell type origin and, increasingly, its molecular characteristics. This latter aspect based primarily upon oncogene gains, tumor suppressor losses, associated transcriptional profiles. However, cancers also characterized profound alterations in cellular metabolism epigenetic landscape. It particularly noteworthy cancer-causing genomic defects not only activate cycle progression, but regulate the opportunistic uptake utilization nutrients, effectively enabling tumors maximize growth drug resistance changing systemic microenvironments. Shifts chromatin architecture central this dynamic behavior. Further, changes nutrient directly affect structure. In review, we describe recent discoveries metabolic reprogramming cancer, especially focus on genomically well-characterized brain tumor, glioblastoma. discuss new mode regulation driven mechanisms, enables cancer cells autonomously iron for their survival. Together, these underscore integration mutations with shifts suggesting means identifying patient subsets suitable specific precision therapeutics.