Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB.

摘要: Abstract Members of the Rho family small GTPases control cell adhesion and motility through dynamic regulation actin cytoskeleton. Although twelve members have been identified, only three these – RhoA, Rac Cdc42 studied in detail. RhoA regulates formation focal adhesions bundling filaments into stress fibres. It is also involved other signalling pathways including gene expression generation lipid second messengers [1,2]. very closely related to two about which much less known: RhoB RhoC (which are approximately 83% identical). Perhaps most intriguing RhoB. largely cytosolic but translocates plasma membrane on activation. RhoB, however, entirely localised face endocytic vesicles [3,4]. This suggests a potential role for regulating traffic; no evidence has presented support this. shown act at regulate clathrin-mediated internalisation transferrin receptor [5] muscarinic acetylcholine [6]. We recently demonstrated that binds effector, PRK1 targets it endosomal compartment [7]. show here acts kinetics epidermal growth factor traffic.