Apigenin and luteolin display differential hypocholesterolemic mechanisms in mice fed a high-fat diet.

摘要: Abstract Hypercholesterolemia is a major risk factor in the development of atherosclerosis. High blood cholesterol can be result increased biosynthesis or reduced elimination system. Increased consumption fruits and vegetables recommended for patients suffering from hypercholesterolemia. The plant food flavones apigenin luteolin have previously been shown to suppress synthesis human hepatocytes. effectiveness these two controlling was examined mouse model present study. Mice were fed high-fat diet at 50 250 ppm mixed diet. After 8 weeks treatment, administration could modulate total serum non-HDL cholesterol. expressions srebf-2 mRNA, Srebp-2 protein Hmgcr decreased livers apigenin-treated mice; meanwhile, AMPK activated this group mice. In contrast, suppressed ncp1l1 induced abcg-5/8 mRNA seen intestinal mucosa luteolin-fed animals. fecal content also observed luteolin-treated These results revealed that cholesterol, whereas promoted summary, study illustrated attenuate feeding-induced hypercholesterolemia different mechanisms.