Milk-soluble formula increases food intake and reduces Il6 expression in elderly rat hypothalami

摘要: The malnutrition of elderly is accompanied by several metabolic dysfunctions especially the alteration energy homeostasis regulation and loss insulin responsiveness. Nutritional recommendations aim to enrich food providing high protein supplements. nutrients that were widely studied composition quality lipids. Despite, numerous studies attempting overcome in through nutritional supplementations; it still necessary study combinations between protein, lipids vitamin D. This could be achieved animal models for malnutrition. In present we investigated impact diet formulae on responsiveness, inflammation hypothalamic gene expression key genes involved control. To mimic malnutrition, old Wistar rats restricted (-50%) during 12 weeks then re-fed 4 with different isocaloric diets: control (C), where milk soluble proteins replaced casein (MSP), a blend dairy fat/rapeseed/DHA (MRD) as fat or full combines (FF). All re-feeding diets contain We conclude that: 1) restriction led up-regulation receptor liver adipose tissue increased TNFα hypothalamus; 2) all groups, similar body weight gain period; 3) induced higher intake fourth week associated reduced IL-6 expression.