Development of ISFET array-based microsystems for bioelectrochemical measurements of cell populations
作者： Sergio Martinoia , Nicola Rosso , Massimo Grattarola , Leandro Lorenzelli , Benno Margesin
DOI: 10.1016/S0956-5663(01)00202-0
关键词:
摘要: Monitoring the bioelectrochemical activity of living cells with sensor array-based microsystems represents an emerging technique in a large area biomedical applications, ranging from basic research to various fields pharmacological analyses. The main appeal is ability these miniaturised perform, real time, non-invasive in-vitro investigations physiological state cell population. In this paper, we present two different designed for multisite monitoring first microsystem, intended cellular metabolism monitoring, consists array 12 spatially distributed ISFETs detect small pH variations induced by second microsystem 40 and 20 gold microelectrodes it has been monitor electrical neurons. This achieved direct coupling neuronal culture ISFET sensitive layer utilising stimulation.
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sci-hub.se 参考文章(22)
Sergio Martinoia, Giuseppe Massobrio, A behavioral macromodel of the ISFET in SPICE Sensors and Actuators B-chemical. ,vol. 62, pp. 182- 189 ,(2000) , 10.1016/S0925-4005(99)00377-9
P Fromherz, A Offenhausser, T Vetter, J Weis, A neuron-silicon junction: a Retzius cell of the leech on an insulated-gate field-effect transistor. Science. ,vol. 252, pp. 1290- 1293 ,(1991) , 10.1126/SCIENCE.1925540
Andreas Offenhäusser, Christoph Sprössler, Mieko Matsuzawa, Wolfgang Knoll, Field-effect transistor array for monitoring electrical activity from mammalian neurons in culture. Biosensors and Bioelectronics. ,vol. 12, pp. 819- 826 ,(1997) , 10.1016/S0956-5663(97)00047-X
ASG Curtis, L Breckenridge, P Connolly, JAT Dow, CDW Wildinson, R Wilson, None, Making real neural nets: design criteria Medical & Biological Engineering & Computing. ,vol. 30, pp. CE33- CE36 ,(1992) , 10.1007/BF02446176
RJA Wilson, L Breckenridge, SE Blackshaw, P Connolly, JAT Dow, ASG Curtis, CDW Wilkinson, None, Simultaneous multisite recordings and stimulation of single isolated leech neurons using planar extracellular electrode arrays Journal of Neuroscience Methods. ,vol. 53, pp. 101- 110 ,(1994) , 10.1016/0165-0270(94)90150-3
Marco Bove, Sergio Martinoia, Massimo Grattarola, Davide Ricci, The neuron-transistor junction: linking equivalent electric circuit models to microscopic descriptions Thin Solid Films. pp. 772- 775 ,(1996) , 10.1016/S0040-6090(95)08443-6
P. Nelson, C Yu, R. Fields, E. Neale, Synaptic connections in vitro: modulation of number and efficacy by electrical activity. Science. ,vol. 244, pp. 585- 587 ,(1989) , 10.1126/SCIENCE.2717942
Markus Meister, Jerome Pine, Denis A. Baylor, Multi-neuronal signals from the retina: acquisition and analysis. Journal of Neuroscience Methods. ,vol. 51, pp. 95- 106 ,(1994) , 10.1016/0165-0270(94)90030-2
A.G.M. Bulloch, N.I. Syed, Reconstruction of neuronal networks in culture Trends in Neurosciences. ,vol. 15, pp. 422- 427 ,(1992) , 10.1016/0166-2236(92)90004-R
Jan Holsheimer, Emiel A Dijkstra, Hilde Demeulemeester, Bart Nuttin, Chronaxie calculated from current–duration and voltage–duration data Journal of Neuroscience Methods. ,vol. 97, pp. 45- 50 ,(2000) , 10.1016/S0165-0270(00)00163-1