Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1

作者: Yukiko Kurihara , Hiroki Kurihara , Hiroshi Suzuki , Tatsuhiko Kodama , Koji Maemura

DOI: 10.1038/368703A0

关键词:

摘要: The endothelin-1 (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient ET-1. These ET-1-/- homozygous die of respiratory failure at birth and have morphological abnormalities the pharyngeal-arch-derived craniofacial tissues organs. ET-1+/- heterozygous mice, which produce lower levels ET-1 than wild-type develop elevated blood pressure. results suggest that is essential for normal development may also play a physiological role cardiovascular homeostasis.

参考文章(43)
K D Bloch, S P Friedrich, M E Lee, R L Eddy, T B Shows, T Quertermous, Structural organization and chromosomal assignment of the gene encoding endothelin. Journal of Biological Chemistry. ,vol. 264, pp. 10851- 10857 ,(1989) , 10.1016/S0021-9258(18)81698-2
A Inoue, M Yanagisawa, Y Takuwa, Y Mitsui, M Kobayashi, T Masaki, The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression. Journal of Biological Chemistry. ,vol. 264, pp. 14954- 14959 ,(1989) , 10.1016/S0021-9258(18)63795-0
J. McKenzie, The First Arch Syndrome Archives of Disease in Childhood. ,vol. 33, pp. 477- 486 ,(1958) , 10.1136/ADC.33.171.477
R Mosqueda-Garcia, T Inagami, M Appalsamy, M Sugiura, R M Robertson, Endothelin as a neuropeptide. Cardiovascular effects in the brainstem of normotensive rats. Circulation Research. ,vol. 72, pp. 20- 35 ,(1993) , 10.1161/01.RES.72.1.20
Issei Komuro, Hiroki Kurihara, Takao Sugiyama, Fumimaro Takaku, Yoshio Yazaki, Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells. FEBS Letters. ,vol. 238, pp. 249- 252 ,(1988) , 10.1016/0014-5793(88)80489-7
Chizuko Koseki, Masashi Imai, Yukio Hirata, Masashi Yanagisawa, Tomoh Masaki, Autoradiographic localization of [125I]-endothelin-1 binding sites in rat brain. Neuroscience Research. ,vol. 6, pp. 581- 585 ,(1989) , 10.1016/0168-0102(89)90047-3
A. Inoue, M. Yanagisawa, S. Kimura, Y. Kasuya, T. Miyauchi, K. Goto, T. Masaki, The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 2863- 2867 ,(1989) , 10.1073/PNAS.86.8.2863
Tomoyuki KUWAKI, Naohiro KOSHIYA, Wei-hua CAO, Hakuo TAKAHASHI, Naohito TERUI, Mamoru KUMADA, MODULATORY EFFECTS OF ENDOTHELIN-1 ON CENTRAL CARDIOVASCULAR CONTROL IN RATS Japanese Journal of Physiology. ,vol. 40, pp. 827- 841 ,(1990) , 10.2170/JJPHYSIOL.40.827
Wei-Hua Cao, Tomoyuki Kuwaki, Miyuki Unekawa, Guang-Yi Ling, Naohito Terui, Mamoru Kumada, Action of endothelin-1 on vasomotor neurons in rat rostral ventrolateral medulla. Journal of Cardiovascular Pharmacology. ,vol. 22, ,(1993) , 10.1097/00005344-199322008-00053