Subnormal retinal oxygenation response precedes diabetic-like retinopathy.

摘要: PURPOSE. Determining which patients are at risk for the development of diabetic retinopathy is expected to greatly improve existing prevention and treatment options. In this study, using an animal model retinopathy, hypothesis was tested that magnetic resonance imaging (MRI) a carbogen inhalation challenge provides important diagnostic information regarding developing retinopathy. METHODS. MRI used measure noninvasively change in oxygen tension along entire inner retina (i.e., from superior ora serrata inferior serrata) during (95% O2/5% CO2) (IOVS 1996;37:2089). Two groups were examined by method two time points: (1) rats fed either normal rat chow (n 5 20) or 50% galactose diet 3.5 months before appearance extensive retinal lesions) (2) 3) 15 30% 4) 18 when lesions present). Retinal biochemical morphometric measurements also obtained. RESULTS. After galactosemia, morphologic lesions, significant (P , 0.05) reduction panretinal oxygenation response observed galactosemic group compared with its age-matched control. These galactose-fed animals displayed significantly larger hemiretina than hemiretina. period present, remained lower their controls. contrast 3.5-month results, Hemiretinal responses not different controls duration. CONCLUSIONS. measurement appears be powerful new noninvasive approach may useful assessing aspects pathophysiology underlying rats. results support our working suggest further research into potential predicting warranted. (Invest Ophthalmol Vis Sci. 1999;40:2100 ‐2105)