Ginsenoside 20(S)‑Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells
作者： JIE LI , TING LIU , LE ZHAO , WEI CHEN , HUILIAN HOU
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摘要: Abstract Cancer cells prefer to metabolize glucose through aerobic glycolysis, known as the Warburg effect. It plays a crucial role in proliferation and progression of cancer cells. However, complete mechanism remains elusive. In recent studies, signal transducer activator transcription 3 (STAT3) signaling has been discovered have roles cancer‑associated changes metabolism. this study, we find that ginsenoside 20(S)‑Rg3, pharmacologically active component traditional Chinese herb Panax ginseng, inhibits glycolysis ovarian by regulating hexokinase 2 (HK2) pyruvate kinase M2 (PKM2). We also show 20(S)‑Rg3 regulates HK2 downregulation p‑STAT3 (Tyr705). Furthermore, overexpression STAT3 weakened suppression effect induced 20(S)‑Rg3. Importantly, treatment represses expression nude mouse xenograft models cancer. Taken together, our results targeting STAT3/HK2 pathway cells, highlighting potentiality be used therapeutic agent for
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