Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor.

摘要: Chronic administration of clomipramine or other serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors to neonatal rats produces behaviours that resemble a depressive state in the adult animal, and this model is therefore regarded as putative animal depression. Alterations activity central 5-HT system are important understanding pathophysiology depression, therefore, we examined whether was associated with changes expression 5-HT1A receptor, 5-HT1B transporter mRNA dorsal raphe nucleus hippocampus. Wistar were injected twice daily 5-chloro-1-[3-(dimethylamino)propyl]-1-(4-fluoro-phenyl)-1,3-dihydroi so-benzofurane, hydrochloride (code Lu 10-134-C) at doses 15 mg kg(-1) vehicle i.p. from postnatal day 8 for 14 days. Groups (n = 10) either killed after last injection left undisturbed 69 days before they killed. The transporter, receptor CA1 hippocampus by means quantitative situ hybridisation histochemistry. Both compounds resulted an increase (40% more than vehicle) (postnatal 22). A small but significant seen clomipramine, not 10-134-C, probably reflecting clomipramine's affinity both noradrenaline transporters well number monoamine sites. Levels unchanged. In contrast, significantly decreased treatment two drugs compared vehicle. No observed any regions these animals. results show persistent behaviour previously shown also mRNA. This long-term alteration gene may result disturbances neurotransmission brain