Nitrogen-containing heterocyclic quinones: a class of potential selective antitumor agents.

摘要: The development of prodrugs that are enzymatically activated into anticancer agents is a promising perspective in cancer therapy. Many nitrogen-containing quinoid heterocycles have been reported to show antitumor effect. principal interest these compounds lies on their potential produce tumor-selective toxicity. Selectivity occurs by difference oxygen tension between normal and tumor tissue levels the required activating enzymes. In this review summary most interesting heterocyclic quinones given together with biological property. SAR studies concerning importance some structural features will be described.