Volumetric approach to the interaction of diglycine in aqueous solutions of sulpha drugs at T = 288.15―308.15K

摘要: Abstract Densities, ρ, were measured for ternary mixture of diglycine in aqueous (0.01, 0.02, 0.03, and 0.04) mol kg−1 sulphanilamide (SAM), sulphanilic acid (SAN), sulphosalicylic (SSAD) dihydrate at T = 288.15–308.15 K, using vibrating tube digital densimeter. Apparent molar volume, V ϕ , has been determined from the experimental densities least-square fitting was carried out calculation limiting apparent volumes values 0 increase following order investigated system: SAN  indicate that diglycine–SSAD interactions are stronger than other two drugs. These data used to calculate transfer Δ t r partial volumes. Transfer parameters have interpreted point view concentration dependence solute–solute solute–solvent interactions. The expansibility E solution drugs positive value decrease with rise temperature. calculated thermal expansion coefficient, α 2 small whereas Hepler's constant, ∂ / T except SSAD. Hydration numbers also determined. variation these temperature clearly suggests roles sulpha