A randomized comparison of the effects of aspirin and clopidogrel on thrombotic risk factors and C-reactive protein following myocardial infarction: the CADET trial.

摘要: A randomized, double-blind multicenter trial-the Clopidogrel and Aspirin: Determination of the Effects on Thrombogenicity (CADET) trial-was carried out to compare effects clopidogrel vs. aspirin thrombotic variables C-reactive protein (CRP), over a 6-month period treatment, in patients with an acute myocardial infarction within previous 3-7 days, who were not scheduled for major surgery including coronary artery bypass grafting. Patients (n = 184) randomly allocated (75 mg day(-1)) or day(-1)). Blood samples taken at baseline then clinic visits 1, 3 6 months. By 1 month, clottable immunonephelometric fibrinogen, D-dimer, von Willebrand factor, factor VIII CRP significantly (P 0.05) any variables, whether potential confounding adjusted for. Similarly, there no differences between treatments difference final values variables. Aspirin thus found have similar this patient population.