Deciphering structure and topology of conserved COG2042 orphan proteins.

作者: Jean Armengaud , Alain Dedieu , Olivier Solques , Jean-Luc Pellequer , Eric Quemeneur

DOI: 10.1186/1472-6807-5-3

关键词:

摘要: Background The cluster of orthologous group COG2042 has members in all sequenced Eukaryota as well many Archaea. The cellular function these proteins ancient origin remains unknown. PSI-BLAST analysis does not indicate a possible link with even remotely-related that have been functionally or structurally characterized. As prototype among orthologs, SSO0551 protein from the hyperthermophilic archaeon Sulfolobus solfataricus was purified to homogeneity for biophysical characterization.

参考文章(42)
John F. Leite, Andrew A. Amoscato, Michael Cascio, Coupled Proteolytic and Mass Spectrometry Studies Indicate a Novel Topology for the Glycine Receptor Journal of Biological Chemistry. ,vol. 275, pp. 13683- 13689 ,(2000) , 10.1074/JBC.275.18.13683
Simon J Hubbard, The structural aspects of limited proteolysis of native proteins Biochimica et Biophysica Acta. ,vol. 1382, pp. 191- 206 ,(1998) , 10.1016/S0167-4838(97)00175-1
Keiryn L. Bennett, Martin Kussmann, Marie Mikkelsen, Peter Roepstorff, Per Björk, Magdalena Godzwon, Poul Sörensen, Chemical cross-linking with thiol-cleavable reagents combined with differential mass spectrometric peptide mapping—A novel approach to assess intermolecular protein contacts Protein Science. ,vol. 9, pp. 1503- 1518 ,(2000) , 10.1110/PS.9.8.1503
Jaap Willem Back, Luitzen de Jong, Anton O. Muijsers, Chris G. de Koster, Chemical cross-linking and mass spectrometry for protein structural modeling. Journal of Molecular Biology. ,vol. 331, pp. 303- 313 ,(2003) , 10.1016/S0022-2836(03)00721-6
S.J. Hubbard, F Eisenmenger, J.M. Thornton, Modeling studies of the change in conformation required for cleavage of limited proteolytic sites. Protein Science. ,vol. 3, pp. 757- 768 ,(1994) , 10.1002/PRO.5560030505
M. Connolly, Solvent-Accessible Surfaces of Proteins and Nucleic Acids Science. ,vol. 221, pp. 709- 713 ,(1983) , 10.1126/SCIENCE.6879170
Q. She, R. K. Singh, F. Confalonieri, Y. Zivanovic, G. Allard, M. J. Awayez, C. C.- Y. Chan-Weiher, I. G. Clausen, B. A. Curtis, A. De Moors, G. Erauso, C. Fletcher, P. M. K. Gordon, I. Heikamp-de Jong, A. C. Jeffries, C. J. Kozera, N. Medina, X. Peng, H. P. Thi-Ngoc, P. Redder, M. E. Schenk, C. Theriault, N. Tolstrup, R. L. Charlebois, W. F. Doolittle, M. Duguet, T. Gaasterland, R. A. Garrett, M. A. Ragan, C. W. Sensen, J. Van der Oost, The complete genome of the crenarchaeon Sulfolobus solfataricus P2. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 7835- 7840 ,(2001) , 10.1073/PNAS.141222098
Kira S Makarova, Eugene V Koonin, Comparative genomics of Archaea: how much have we learned in six years, and what's next? Genome Biology. ,vol. 4, pp. 115- 115 ,(2003) , 10.1186/GB-2003-4-8-115
D. E. Kim, D. Chivian, D. Baker, Protein structure prediction and analysis using the Robetta server Nucleic Acids Research. ,vol. 32, pp. 526- 531 ,(2004) , 10.1093/NAR/GKH468