Hyaluronan synthase gene and uses thereof
作者： Paul H. Weigel , Paul DeAngelis , Kshama Kumari
DOI:
关键词:
摘要: The present invention relates to a nucleic acid segment having coding region encoding enzymatically active Streptococcus equisimilis hyaluronate synthase (seHAS), and the use of this in preparation recombinant cells which produce its hyaluronic product. Hyaluronate is also known as or hyaluronan.
lens.org参考文章(127)
Semih Erhan, Protein polymer grafts ,(1987)
Sten Ståhl, Method and means for the production of hyaluronic acid ,(1995)
E. R. Moxon, J. S. Kroll, The Role of Bacterial Polysaccharide Capsules as Virulence Factors Current Topics in Microbiology and Immunology. ,vol. 150, pp. 65- 85 ,(1990) , 10.1007/978-3-642-74694-9_4
H Kato, T Tanaka, T Nishioka, A Kimura, J Oda, Role of cysteine residues in glutathione synthetase from Escherichia coli B. Chemical modification and oligonucleotide site-directed mutagenesis. Journal of Biological Chemistry. ,vol. 263, pp. 11646- 11651 ,(1988) , 10.1016/S0021-9258(18)37833-5
Frederic Neftel, Implantable device for estimating glucose levels ,(1993)
P Prehm, Hyaluronate is synthesized at plasma membranes Biochemical Journal. ,vol. 220, pp. 597- 600 ,(1984) , 10.1042/BJ2200597
Peter Prehm, Michael O'regan, Irene Martini, Manfred Lansing, Enzymatic preparation of polysaccharides ,(1995)
O Mitsubishi Rayon Co. Ltd. Numazawa, O Mitsubishi Rayon Co. Ltd. Miyamori, O Mitsubishi Rayon Co. Ltd. Onishi, O Mitsubishi Rayon Co. Ltd. Sakimae, Ryozo C, Takao C, Akihiro C, Hisao C, Method of producing hyaluronic acid ,(1987)
B.A. Dougherty, I. van de Rijn, Molecular characterization of hasA from an operon required for hyaluronic acid synthesis in group A streptococci. Journal of Biological Chemistry. ,vol. 269, pp. 169- 175 ,(1994) , 10.1016/S0021-9258(17)42330-1
Mary Louise Augustine, Andrew P. Spicer, John A. McDonald, Gene encoding hyaluronan synthase ,(1996)