Immunity after treatment of human schistosomiasis: association between IgE antibodies to adult worm antigens and resistance to reinfection

摘要: Previous studies in school children have demonstrated the slow development with age of resistance to reinfection after chemotherapy Schistosoma mansoni infections, and indicated that inappropriate ("blocking") antibody responses prevent expression immunity young children. The present study was designed investigate further nature protective responses, by serological on a group 151 S. mansoni-infected individuals resident an endemic area Machakos District, Kenya. Antibody levels against various antigens blood samples before treatment were related intensity previous infections; antibodies taken 6 months cumulative rates over following 30 months. IgE adult-worm antigen preparation correlated positively negatively reinfection. In contrast, other life-cycle stages showed either no relationship or reverse correlation. Furthermore, isotypes correlations correlation could be for different preparations adult worms, including periodate-treated presumptively depleted carbohydrate epitopes. For both intact preparations, multiple regression analysis results less than equal 16 years old effect allowing age, although this not observed previously studied Western blot revealed limited set recognized IgE, among which 22 kDa prominent. qualitative presence also shown lack subsequent