Chemoselective catalytic reduction of conjugated α,β-unsaturated ketones to saturated ketones via a hydroboration/protodeboronation strategy

摘要: A novel copper-catalyzed chemoselective reduction of a carbon–carbon double or triple bond to single in α,β-unsaturated ketones is developed. This reaction proceeds under hydrogen gas stoichiometric metal hydride free conditions. Saturated were obtained good excellent yields with broad substrate scope. Mechanistic studies reveal that the two atoms come from H2O system. Thus this represents highly efficient, and remarkably strategy.