Applying a perceptions and practicalities approach to understanding nonadherence to antiepileptic drugs

摘要: Summary Objective Nonadherence to antiepileptic drugs (AEDs) is a common cause of poor seizure control. This study examines whether reported adherence AEDs related variables identified in the National Institute for Health and Clinical Excellence (NICE) Medicines Adherence Guidelines as being important adherence: perceptual factors (AED necessity beliefs concerns), practical (limitations capability resources), perceptions involvement treatment decisions. Methods was cross-sectional people with epilepsy receiving AEDs. Participants completed an online survey hosted by Epilepsy Society (n = 1,010), or audit during inpatient admission 118). Validated questionnaires, adapted epilepsy, assessed (Medication Report Scale [MARS]), (Beliefs about Questionnaire [BMQ]), patient decisions (Treatment Empowerment [TES]). Results Low AED (doubts necessity: t(577) 3.90, p < 0.001; concerns: t(995) 3.45, 0.001), limitations resources (t(589) 7.78, lack (t(623) 4.48, 0.001). In multiple logistic regression analyses, these significantly (p 0.001) increased variance adherence, above that which could be explained age clinical (seizure frequency, type, duration, number prescribed). Significance Variables NICE potentially were found These are modifiable. Interventions support optimal should tailored address doubts concerns harm, overcome difficulties, while engaging patients