Dose-related growth deficits in LS but not SS mice prenatally exposed to alcohol.
作者： David M Gilliam , Lori E Kotch
DOI: 10.1016/0741-8329(95)02010-1
关键词:
摘要: Genetically based alcohol sensitivity may influence the severity of alcohol-related birth defects. To examine this question, measures growth and survival were examined in offspring sensitive Long-Sleep (LS) alcohol-resistant Short-Sleep (SS) mouse lines following prenatal ethanol exposure. Pregnant LS SS mice received an dose either 6 or 8 g/kg/day from days 7 through 18 pregnancy. Control groups a maltose-dextrin solution made isocaloric to dose. Ethanol solutions administered as split doses, h apart, via gavage. Nonintubated lab chow control also included for both lines. Offspring fostered at lactating outbred stock. Pregnancy was longer ethanol-treated dams compared groups, whereas pregnancy length similar controls. Prenatal exposure resulted dose-related deficits but not litters. Line differences postnatal response suggest maternal fetal
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