Non-canonical Activation of Receptor Tyrosine Kinases in Cancer Progression.
作者： Hiroaki Sakurai
DOI: 10.1248/YAKUSHI.16-00229-4
关键词:
摘要: Receptor tyrosine kinases (RTKs) are known to be key regulators of cancer cell proliferation, migration, invasion and metastatic spread. Ligand-binding the extracellular domain triggers canonical activation intracellular kinase domain. In contrast, it has become evident that RTKs also regulated by non-canonical kinase-independent mechanisms via phosphorylation their serine/threonine residues. this review, I mainly introduce our recent findings on regulation epidermal growth factor receptor (EGFR), ErbB2 erythropoietin-producing hepatocellular A2 (EphA2), discuss roles in progression resistance targeted agents. Further characterization will contribute development new target therapies.
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